Eroxon - ED Cream is coming

[newhere456]

Looks like there is another ED treatment on its way to the market "Eroxon",  in this case a topical cream/gel that once applied "is clinically proven to help you get an erection within 10 minutes"

Some links that may be of interest:

External Link/Members Only
External Link/Members Only

[signy]

I can't see escorts being happy to provide OWO if you've got that on you. Even if you claim to have showered thoroughly.

[alabama1]

I can't see escorts being happy to provide OWO if you've got that on you. Even if you claim to have showered thoroughly.

I would imagine that it would be applied after OWO. 

[Doc Holliday]

I would imagine that it would be applied after OWO. 

Why the sarcasm?

So what do you do in ten minutes after OWO whilst it allegedly works?

[alabama1]

Why the sarcasm?

So what do you do in ten minutes after OWO whilst it allegedly works?

It,s not sarcasm, it's common sense that you wouldn't put it on before OWO isn't it 

[MissWolf]

It,s not sarcasm, it's common sense that you wouldn't put it on before OWO isn't it 

Sadly not, if guys can put on delay cream that sends our mouths and throats numb and tingling without telling us then why would they inform us they have put this cream on?

I've had a couple of really nasty experiences with  declared delay cream and it can take a couple of hours to wear off.

[alabama1]

Sadly not, if guys can put on delay cream that sends our mouths and throats numb and tingling without telling us then why would they inform us they have put this cream on?

I've had a couple of really nasty experiences with  declared delay cream and it can take a couple of hours to wear off.

Maybe The Doc is speaking from experience then. 

[Doc Holliday]

It,s not sarcasm, it's common sense that you wouldn't put it on before OWO isn't it 

 

[contentguy]

Well, I’ll take some relief that it’s a new drug so no bollocks conversation is necessary about generic versions!

[Munter84]

Imagine getting some of that stuff in your eye... it wouldn't improve your sexual performance, but it'd make you look hard.

I'll get me coat.

[Doc Holliday]

I hadn't heard of this but I have just found the scientific studies which I will have a look at tomorrow.

Given that this is Glyceryl Trinitrate gel, I would expect the vasodilation effect to indeed be quite rapid, as it is when used for angina administered via the oral mucous membrane (either tablet dissolving under the tongue or in spray application).

However GTN has a very short half life of around 5 minutes and is completely removed from the body within half an hour so I suspect the effect will be short lived. That said five minutes penetration is enough for many people?

[alabama1]

I hadn't heard of this but I have just found the scientific studies which I will have a look at tomorrow.

Given that this is Glyceryl Trinitrate gel, I would expect the vasodilation effect to indeed be quite rapid, as it is when used for angina administered via the oral mucous membrane (either tablet dissolving under the tongue or in spray application).

However GTN has a very short half life of around 5 minutes and is completely removed from the body within half an hour so I suspect the effect will be short lived. That said five minutes penetration is enough for many people?

Doc by name but not by nature. Don't you think you should be leaving all things medical to professionals 

[Stevelondon]

Five minutes penetration!!!!!

I’m not usually a two pop guy 

[FiveKnuckles]

Well, I’ll take some relief that it’s a new drug so no bollocks conversation is necessary about generic versions!

Make a date for 2040.  In the meantime, let's discuss Erexanol gel. 

[Iloveoral]

So what do you do in ten minutes after OWO whilst it allegedly works?

I was thinking RO ?
If you get 5mins out this stuff 15 bookings might become more of a thing, save a few quid for the gas and electric bill   

[JustaPunter]

I hadn't heard of this but I have just found the scientific studies which I will have a look at tomorrow.

Given that this is Glyceryl Trinitrate gel, I would expect the vasodilation effect to indeed be quite rapid, as it is when used for angina administered via the oral mucous membrane (either tablet dissolving under the tongue or in spray application).

However GTN has a very short half life of around 5 minutes and is completely removed from the body within half an hour so I suspect the effect will be short lived. That said five minutes penetration is enough for many people?

I would assume once the vasodilation occurs it would be like a normal erection.

Assuming the person doesn’t suffer from venous leakage.

Perhaps those affected in that way could also use a construction ring in much the same way they might do if using a vacuum pump with a construction ring?

[mr.bluesky]

Well, I’ll take some relief that it’s a new drug so no bollocks conversation is necessary about generic versions!

I thought you put it on your cock not your bollocks 🤔   

[JontyR]

venous leakage.

Any one got the John Peel Meme?

[Doc Holliday]

I was thinking RO ?

Indeed and just as she is reaching her plateau you pop your head up and say "Sorry luv yer times up" 

Anyway have looked at this further out of interest.

Glycerol Trinitrate (GTN) has been in use since way before I was born, so is far from a new drug so does not need all the usual lengthy trials in terms of safety etc. What is different is this is an ‘off label’ use and also the UK development company Futura Medical is claiming a unique method of delivery DermaSys® with the mode of action of its topical gel containing the GTN (which presumably they have patented?)
 
The story appears to start in 2018 with this first trial involving around 300 volunteers and which showed its efficacy to be ‘statistically’ significant.
External Link/Members Only

There is a second trial in 2020 to look more at safety among partners and which found very minimal side effects.
External Link/Members Only

Finally the FDA insisted that a phase 3 trial be conducted to examine use over a longer period of time (24weeks) and once again the results seem favourable. One aspect of this is that tolerance can occur with GTN with repeated and frequent use but this trial suggests that is not an issue. Results were announced last year. This is a press release of this trial
External Link/Members Only

Some points I have picked up on.

The big plus is the rapid onset. My suspicion is still that the peak period of effectiveness is around 10 minutes after application and then declining to zero by up 30 mins, but I cannot find anything to confirm this.

The early study suggests effectiveness is maximised in those with mild to moderate ED. Later study suggests this is also statistically effective with moderate to severe.

It is interesting that Tadalfil 5mg was used as the comparator (which is the low daily dose) and not the 'on demand' dose of 10 to 20mg? It does also say that whilst Tadalfil scored better in terms of the strength of erection, the gel scored better overall largely due to being quick acting and with less side effects.

Regarding safety with partners it says that around 75% of  the active ingredient has been absorbed from the glans penis within 5 minutes, with none remaining by 10 minutes and as a result there should be very little exposure to the partner via vaginal mucous membranes, assuming a ten minute delay prior to penetration. Obviously condom use would reduce that considerably further. Only four cases of partner adverse effects in the trials.

I cannot find anything about how often the gel is recommended for use? In the trial participants had to leave a one week gap, but that is mainly to ensure there is zero chance of any remaining residual effects.

In terms of punting and given this 5 to10 minute onset, the only way I can see this working is if the gel is applied during the booking and therefore with the knowledge and consent of the SP. It is undoubtedly more suited to couples in relationships and where ED is an issue?

Very much a case of wait and see when opened up to a wider market which appears is now in sight in the UK. I shall follow with interest.

[Strawberry]

Indeed and just as she is reaching her plateau you pop your head up and say "Sorry luv yer times up" 

Anyway have looked at this further out of interest.

Glycerol Trinitrate (GTN) has been in use since way before I was born, so is far from a new drug so does not need all the usual lengthy trials in terms of safety etc. What is different is this is an ‘off label’ use and also the UK development company Futura Medical is claiming a unique method of delivery DermaSys® with the mode of action of its topical gel containing the GTN (which presumably they have patented?)
 
The story appears to start in 2018 with this first trial involving around 300 volunteers and which showed its efficacy to be ‘statistically’ significant.
External Link/Members Only

There is a second trial in 2020 to look more at safety among partners and which found very minimal side effects.
External Link/Members Only

Finally the FDA insisted that a phase 3 trial be conducted to examine use over a longer period of time (24weeks) and once again the results seem favourable. One aspect of this is that tolerance can occur with GTN with repeated and frequent use but this trial suggests that is not an issue. Results were announced last year. This is a press release of this trial
External Link/Members Only

Some points I have picked up on.

The big plus is the rapid onset. My suspicion is still that the peak period of effectiveness is around 10 minutes after application and then declining to zero by up 30 mins, but I cannot find anything to confirm this.

The early study suggests effectiveness is maximised in those with mild to moderate ED. Later study suggests this is also statistically effective with moderate to severe.

It is interesting that Tadalfil 5mg was used as the comparator (which is the low daily dose) and not the 'on demand' dose of 10 to 20mg? It does also say that whilst Tadalfil scored better in terms of the strength of erection, the gel scored better overall largely due to being quick acting and with less side effects.

Regarding safety with partners it says that around 75% of  the active ingredient has been absorbed from the glans penis within 5 minutes, with none remaining by 10 minutes and as a result there should be very little exposure to the partner via vaginal mucous membranes, assuming a ten minute delay prior to penetration. Obviously condom use would reduce that considerably further. Only four cases of partner adverse effects in the trials.

I cannot find anything about how often the gel is recommended for use? In the trial participants had to leave a one week gap, but that is mainly to ensure there is zero chance of any remaining residual effects.

In terms of punting and given this 5 to10 minute onset, the only way I can see this working is if the gel is applied during the booking and therefore with the knowledge and consent of the SP. It is undoubtedly more suited to couples in relationships and where ED is an issue?

Very much a case of wait and see when opened up to a wider market which appears is now in sight in the UK. I shall follow with interest.

Like Miss Wolf I have encountered orally encountered the effects from delay spray and condoms, so I too am wondering if there are any contraindications or notes about oral ingestion. Does sound as if the risk of exposure could be limited to the first ten minutes after application.

As you say consent, informed consent.

[Colston36]

Doc by name but not by nature. Don't you think you should be leaving all things medical to professionals 

He seems very well informed. Why do you do little else than put people down?

[Thephoenix]

Doc by name but not by nature. Don't you think you should be leaving all things medical to professionals 

Hidden Image/Members Only

[Thephoenix]

I have plenty of free time......how did I miss the trials?

Due to being well past my sell by date, various ailments, plus  side effects/interactions between ED meds and prescription drugs, this sounds appealing, particularly as my modus operandi is exclusively fbsm with a hopeful HE.

I'm resigned to just enjoying an occasional sensual massage now so I guess I would nip into the bog on arrival, splash it all over, then fit a cock ring (or tie a bowline on the bight) to maintain the swelling.

Of course it would depend on whether the effects last long enough, or before my dick falls off.

[Vice Admiral]

This truly miraculous cream
Could be every old geezer’s wet dream.
With this to assist,
No whore need be missed
– He can always take one for the team!

[scutty brown]

I hadn't heard of this but I have just found the scientific studies which I will have a look at tomorrow.

Given that this is Glyceryl Trinitrate gel, I would expect the vasodilation effect to indeed be quite rapid, as it is when used for angina administered via the oral mucous membrane (either tablet dissolving under the tongue or in spray application).

However GTN has a very short half life of around 5 minutes and is completely removed from the body within half an hour so I suspect the effect will be short lived. That said five minutes penetration is enough for many people?

glyceryl trinitrate
so barebacking someone with a heart condition is a bad idea

[s0whatsnew?]

The Admiral's vice
is really quite nice.
Its to give us a laugh
by sitting on his arse
and writing his poem in a trice.

[Milfman1112]

He seems very well informed. Why do you do little else than put people down?

My thoughts exactly.

[tynetunnel]

Doc by name but not by nature. Don't you think you should be leaving all things medical to professionals 

You do seem to have an increasingly intolerant and unpleasant attitude. I can’t help but think maybe you await unmasking, and so revealing the real you 

[Jonestown]

It’s from the DM I know, but some of it might be true:-

External Link/Members Only

[big-al93]

Didn't see it myself, but was talked about on this morning today apparently.

[Strawberry]

Is it this;

https://www.ukpunting.com/index.php?topic=369456.msg3791150#msg3791150

[Jonestown]

Is it this;

https://www.ukpunting.com/index.php?topic=369456.msg3791150#msg3791150

Yes, Eroxon

[MysteryManNo.7]

Doc by name but not by nature. Don't you think you should be leaving all things medical to professionals 

Who shit in your cornflakes this morning?

[RandomGuy99]

Why have one stream about a topic when you can have 2 or maybe 16 in the future?

[Jonestown]

Why have one stream about a topic when you can have 2 or maybe 16 in the future?

My error, I’ve already asked for them to be merged.

[Doc Holliday]

I hadn't heard of this but I have just found the scientific studies which I will have a look at tomorrow.

Given that this is Glyceryl Trinitrate gel, I would expect the vasodilation effect to indeed be quite rapid, as it is when used for angina administered via the oral mucous membrane (either tablet dissolving under the tongue or in spray application).

However GTN has a very short half life of around 5 minutes and is completely removed from the body within half an hour so I suspect the effect will be short lived. That said five minutes penetration is enough for many people?

This product has changed from the discussion six weeks ago. It has been launched no longer containing glyceryl trinitrate. In fact it no longer contains an active ingredient? 

They appear to be claiming that it works the same without it, by the action of the gel alone, initially cooling and the then warming up the tissues which leads to Nitrous Oxide production?

Yet all the studies over the last five years have been on the version with glceryl trinitrate?

Retailing at £24.99 for 4 treatments it's not cheap either? All very odd?

[puntingking]

i used to agree with ED drugs but now i think that it can't be good for the human body to keep pumping your body with unnatural ingredients. Just stick to natural non processed foods - fruits, veg, fresh fish & exercise daily.   

[JontyR]

They appear to be claiming that it works the same without it, by the action of the gel alone,

Sooooo... basically... they are saying... that if you rub your cock you may get a stonk on?

[sonic999]

I can't see escorts being happy to provide OWO if you've got that on you. Even if you claim to have showered thoroughly.

   Could end up with a stiff neck.

[Thephoenix]

i used to agree with ED drugs but now i think that it can't be good for the human body to keep pumping your body with unnatural ingredients. Just stick to natural non processed foods - fruits, veg, fresh fish & exercise daily.

Ahh!...them were the daze!

[dsr]

According to the Boots website, here are the ingredients:

Aqua, ethanol (35%), propylene glycol, glycerine, carbomer, potassium hydroxide

It's alcohol gel for your knob, pretty much.  Hard pass.

[Doc Holliday]

Sooooo... basically... they are saying... that if you rub your cock you may get a stonk on?

I've just found a trial where 46 males were asked to lie naked on the bed watching pornography and to rub their penis for 2 minutes (they provided a timer) 92% of the group reported they achieved an erection, although the quality of this was variable.

For comparison they asked another group of 43 males to lie naked on the same bed but with no touching. Only 21% reported achieving an erection within the 2 minutes and the scores for the quality of the erection was rated as poorer compared to the first group.

The conclusion was that whilst pornography alone may help achieve erection, the effect is enhanced if accompanied by digital penile stimulation.

The trial was repeated with the same cohort of volunteers, but this time was extended to 7 minutes. The first group reported further improvements in erection quality beyond two minutes, but in 22% of participants this rapidly deteriorated at some point before the end of the trial.

This rapid deterioration was only observed in 1% of the second group. This further supported the conclusion that continued digital stimulation beyond 2 minutes is important in relation to the quality of an erection, but the improvement in some men may not be long lasting.

The reason why this sudden 'drop off' occurred in some people, needs to being investigated in further trials (subject to further funding becoming available).

[mancsguy1975]

According to the Boots website, here are the ingredients:

Aqua, ethanol (35%), propylene glycol, glycerine, carbomer, potassium hydroxide

It's alcohol gel for your knob, pretty much.  Hard pass.

Wonder if Deep Freeze you use for musular aches and pains would do the same job ? 

Hidden Image/Members Only

[JontyR]

I've just found a trial where 46 males were asked to lie naked on the bed watching pornography and to rub their penis for 2 minutes (they provided a timer) 92% of the group reported they achieved an erection, although the quality of this was variable.

For comparison they asked another group of 43 males to lie naked on the same bed but with no touching. Only 21% reported achieving an erection within the 2 minutes and the scores for the quality of the erection was rated as poorer compared to the first group.

The conclusion was that whilst pornography alone may help achieve erection, the effect is enhanced if accompanied by digital penile stimulation.

The trial was repeated with the same cohort of volunteers, but this time was extended to 7 minutes. The first group reported further improvements in erection quality beyond two minutes, but in 22% of participants this rapidly deteriorated at some point before the end of the trial.

This rapid deterioration was only observed in 1% of the second group. This further supported the conclusion that continued digital stimulation beyond 2 minutes is important in relation to the quality of an erection, but the improvement in some men may not be long lasting.

The reason why this sudden 'drop off' occurred in some people, needs to being investigated in further trials (subject to further funding becoming available).

I wonder how many of the participants came to the same conclusion.

[Private Parts]

Reading this thread it strikes me that any of our readers that may have inadvertently put a dollop of Vick Chest rub on their member will know exactly what to expect with this new’ product.

Ouch!
 

[Doc Holliday]

that may have inadvertently put a dollop of Vick Chest rub on their member

Ouch!

Run me through the sequence of events leading to 'inadvertently'? 

[Thecunninglinguist]

Like Miss Wolf I have encountered orally encountered the effects from delay spray and condoms, so I too am wondering if there are any contraindications or notes about oral ingestion. Does sound as if the risk of exposure could be limited to the first ten minutes after application.

As you say consent, informed consent.

I totally agree with the above and understand what you are saying. Within the Eroxon.com information section on the use, it does say that it is safe for oral sex. Partners should still be made aware of course but it may alleviate concerns somewhat. 

[Private Parts]

Run me through the sequence of events leading to 'inadvertently'? 

Years ago I had a severe groin strain following sport. This eejit rubbed Vick into the aching area and inadvertently administered a blob to the old man.
Years later Deep heat had a similar effect.

There 

[Jonestown]

Years ago I had a severe groin strain following sport. This eejit rubbed Vick into the aching area and inadvertently administered a blob to the old man.
Years later Deep heat had a similar effect.

There 

Have you tried putting tooth paste in your eye, that really hurts; or perhaps a piece of peeled ginger in your rusty sherif’s badge ?

[Private Parts]

Have you tried putting tooth paste in your eye, that really hurts; or perhaps a piece of peeled ginger in your rusty sherif’s badge ?

Gentlemen we are in danger of attracting the wrong sort here.
I will not respond