The Mercure by Piccadilly is good.
You enter off the street into a large empty hallway which takes you to the lift and stairs.
Once in the lift you press your floor and it goes straight there, not stopping at reception which is (I think) on the 2nd floor.
The Renaissance at the end of Deansgate has a car park below, and again you get in the lift in the car park and straight up to the rooms.